Inflammatory Pathways

The pathway to inflammation

In UC, the activity of pro- and anti-inflammatory mediators is dysregulated, provoking an exaggerated immune response and initiating a chronic inflammatory cycle.^1-3

Proinflammatory mediators, such as TNF-a and IL-13, recruit immune cells to sites of inflammation through intracellular signalling pathways. These pathways include the JAK-STAT, MAPK, and NF-kB pathways.^4,5

Dysregulation of JAK-STAT, MAPK, or NF-kB activity is associated with inflammatory cytokine secretion through transcription factors. Excessive inflammatory cytokine production can lead to tissue damage, haemodynamic changes, and ultimately organ failure.⁴